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The nominees were announced this morning.

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The 2018 Emmy Award nominations are finally here! Samira Wiley and Ryan Eggold announced the Primetime Emmy Award nominees this morning. Game of Thrones led the nominations with 22 total, followed by Westworld and Saturday Night Live , which scooped up 21 nominations each.

The 2018 Primetime Emmy Awards, which will honor the best television performances and programs of the past year, will be hosted by Michael Che and Colin Jost on September 17 at 8 p.m. ET / 5 pm.m PT on NBC. Take a peek at the full list of 2018 Emmy Award nominees here to see who might bring home the gold this fall:

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Outstanding Lead Actress in a Comedy Series

Pamela Adlon – Better Things

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Allison Janney – Mom

Issa Rae – Insecure

Tracee Ellis Ross – Black-ish

Lily Tomlin – Grace and Frankie

Outstanding Lead Actor in a Comedy Series

Donald Glover – Atlanta

Anthony Anderson – Black-ish

Ted Danson – The Good Place

Larry David – Curb Your Enthusiasm

Bill Hader – Barry

William H. Macy - Shameless

Outstanding Supporting Actress in a Comedy Series

Zazie Beetz – Atlanta

Laurie Metcalf – Roseanne

Leslie Jones – Saturday Night Live

Alex Borstein – The Marvelous Mrs. Maisel

Betty Gilpin – GLOW

Aidy Bryant – Saturday Night Live

Kate McKinnon – Saturday Night Live

Megan Mullally – Will Grace

Outstanding Supporting Actor in a Comedy Series

Brian Tyree Henry – Atlanta

Louie Anderson – Baskets

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Amanita phalloides, commonly known as the death cap, poisonous mushroom in the forest.
Amanita phalloides, commonly known as the death cap, poisonous mushroom in the forest.

The death-cap mushroom has a long history as a tool of murder and suicide, going back to ancient Roman times. The fungus, Amanita phalloides , produces one of the world's deadliest toxins: α -amanitin. While it may seem ill-advised, researchers are eager to synthesize the toxin because studies have shown that it could help fight cancer. Scientists now report in the Journal of the American Chemical Society how they overcame obstacles to synthesize the death-cap killer compound.

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-Amanitin achieves its impressive deadliness by acting as a potent inhibitor of RNA polymerase II, the enzyme primarily responsible for transcribing genes into the messenger molecule RNA. Using -amanitin bound to antibodies against tumor molecules, cancer researchers have reportedly cured mice of pancreatic cancer. These conjugates are currently in human trials; however, the only way to obtain -amanitin so far has been to harvest mushrooms, which is time-consuming and results in relatively small amounts of the compound. Synthetic production approaches have been hampered by -amanitin's unusual bicyclic structure, among other tricky features. David M. Perrin and colleagues decided to take on the challenge to produce the toxin in the laboratory, once and for all.

The researchers had to work through three key obstacles to produce -amanitin in the laboratory: production of the "oxidatively delicate" 6-hydroxy-tryptathionine, the an enantio- selective synthesis of (2,3,4)-4,5-dihydroxy-isoleucine and a diastereoselective sulfoxidation to favor the ()-sulfoxide. Due to its toxic nature, the researchers limited production to less than a milligram, but based on their results, they are confident that good yields are can be readily obtained by scaling up the process. The researchers also say that the development of this synthetic route will enable chemists to attenuate the toxicity and potentially improve -amanitin's activity against cancer, something that is only made possible by the use of synthetic derivatives.

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Journal Reference :

Synthesis of the Death-Cap Mushroom Toxin α-Amanitin
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